Vitamin B12

June 29th, 2009

We at the British Society for Ecological Medicine (BSEM) have been talking to the Pernicious Anaemia Society (PAS). Martyn Hooper and his colleagues there have achieved a remarkable amount, with 3,500 members after just two years, and a questionnaire that identifies several key symptoms of B12 deficiency about which none of us knew — the “strange tiredness” and “the gulps” for instance. We are looking forward to working with them, both to help sufferers and to prove that B12 deficiency is a real problem for many people. More of that on our website.

Here I want to talk about my own experiences with B12, which I’ve been using for more than 20 years — although we have learnt more all the time since then.

The first thing to say is that B12 is extremely safe. In all that time I have seen one instance of adverse effects, and that was back when we used cyanocobalamin — the original version if you like — and in a complicated case with other problems. Since we have used methylcobalamin and hydroxocobalamin the only adverse effect I have known is one male patient who called me from his car; he was on the way to casualty because just after the injection of B12 that I gave him his urine had turned pink! I was able to reassure him that it was simply overflow of the B12 he had received.

I don’t know why so many doctors are nervous of B12, and reluctant to give more than the official dose, when so many medications have much more severe and more frequent side-effects.

In 1991, in the Journal of Nutritional and Environmental Medicine, we published a “Classic Paper” from 1956, by neurologist Prof J MacDonald Holmes, called “Cerebral Manifestations of Vitamin B12 Deficiency”. The doctor reported that many patients experienced mental or neurological symptoms either before or without blood changes. The main symptoms were;

  • Pronounced slowing of mental processes      100%
  • Confusion and memory defect                          100%
  • Depression                                                           50%
  • Delusions                                                              35%

— sound familiar at all? In fact it was not new even then; we referenced a paper in the Lancet in 1929 which linked pernicious anaemia with mental changes, which it said may precede it by “many months”. As a point of interest, vitamin B12 was first isolated in 1946.

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One Response to “Vitamin B12”

  1. Philip Brown says:

    Hello,

    Can you advise how I can buy the 5,000 and 20,000 unit methylcobalamin lozenges you refer to?
    My mobile number is 07818 063503 if it is more convenient to ring.

    Thank you for your time.

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